Ethanol inhibits NMDA-activated ion current in hippocampal neurons
نویسندگان
چکیده
منابع مشابه
Corrigendum: Activation of transient receptor potential vanilloid 4 increases NMDA-activated current in hippocampal pyramidal neurons
The glutamate excitotoxicity, mediated through N-methyl-d-aspartate receptors (NMDARs), plays an important role in cerebral ischemia injury. Transient receptor potential vanilloid 4 (TRPV4) can be activated by multiple stimuli that may happen during stroke. The present study evaluated the effect of TRPV4 activation on NMDA-activated current (INMDA) and that of blocking TRPV4 on brain injury aft...
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Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons. This neurosteroid staining was increased following 15 min administration of 60 mm but not 20 mm ethanol, and the enhancement was blocked by finasteride and dutasteride, selective inhibitors of 5α-reductase...
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ژورنال
عنوان ژورنال: Science
سال: 1989
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.2467382